病前抗血小板治疗对急性缺血性脑卒中静脉溶栓效果的影响

摘要：[Abtract] Objective To analyze and study the impact of premorbid antiplatelet therapy on the efficacy and safety of travenous thrombolysis for patients with acute ischemic stroke. Methods The clinical data of 258 patients with acute ischemic stroke who were admitted and treated with travenous thrombolysis within 6 hours after the onset in our hospital during September 2010 and December 2012 were retrospectively analyzed. 125 patients who were given premorbid antiplatelet therapy and the other 133 who were not given were assigned to observation group and control group, respectively. The recovery of neurological function was eval-uated by using modified Rankin scale. Results Within 90 days after travenous thrombolysis, the rate of intracranial hemorrhage, mortality and good prognosis of the observation group and those of the control groups were 11.2%, 5.6%, 5.52% and 8.27%, 4.51%, 5.93%, respectively, and the differences between the indicators above of the two groups were not statistically significant (P>0.05). Conclusion Premorbid antiplatelet therapy, which has little effect on the efficacy of travenous thrombolysis for patients with acute ischemic stroke, is not the reference index which must be considered for intravenous thrombolysis.